Anti-Fibronectin Aptamer Modifies Blood Clot Pattern and Stimulates Osteogenesis: An Ex Vivo Study.
Natacha Malu Miranda da CostaLudovica ParisiBenedetta GhezziLisa ElviriSergio Luis Scombatti de SouzaArthur Belém Novaes JúniorPaulo Tambasco de OliveiraGuido Maria MacalusoDaniela Bazan PaliotoPublished in: Biomimetics (Basel, Switzerland) (2023)
The SCA functionalization with fibronectin aptamers may alter key morphological and functional features of blood clot formation, and provides a selective expression of proteins related to osteo differentiation. Additionally, aptamers increase TGF-b1 gene expression, which is highly associated with improvements in regenerative therapies.