Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice.

Yang YuAnissa GambleRena PawlickAndrew R PepperBassem SalamaDerek TomsGolsa RazianCara EllisAntonio BruniBoris Gala-LopezJia Lulu LuHeather VovkoCecilia ChiuShaaban AbdoTatsuya KinGreg KorbuttA M James ShapiroMark Ungrin

Published in: Diabetologia (2018)

The ability to efficiently reformat dissociated islet cells into engineered pseudoislets with improved properties has high potential for both research and therapeutic applications.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
induced pluripotent stem cells
high fat diet induced
pluripotent stem cells
type diabetes
oxidative stress
human health
risk assessment
skeletal muscle
wild type