Lipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study.
Carla Perpiñá-ClériguesSusana MelladoJosé F Català-SenentFrancesc IbáñezPilar CostaMiguel MarcosConsuelo GuerriFrancisco García-GarcíaConsuelo GuerriPublished in: Biology of sex differences (2023)
Our results suggest that binge ethanol drinking in human female adolescents leads to a higher content of plasma EV lipid species associated with EV biogenesis and the propagation of neuroinflammatory responses than in males. In addition, we discovered greater differences in lipid abundance between sexes in WT mice compared to TLR4-KO mice. Our findings also support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation during adolescence.
Keyphrases
- young adults
- physical activity
- endothelial cells
- fatty acid
- high fat diet induced
- high glucose
- toll like receptor
- inflammatory response
- immune response
- lipopolysaccharide induced
- traumatic brain injury
- induced pluripotent stem cells
- diabetic rats
- cognitive impairment
- antibiotic resistance genes
- lps induced
- wild type
- type diabetes
- insulin resistance
- alcohol consumption
- nuclear factor
- genetic diversity