Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway.
María Luisa CastejónT MontoyaC Alarcón-de-la-LastraA González-BenjumeaM V Vázquez-RománM Sánchez-HidalgoPublished in: Food & function (2021)
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease without an effective and safe treatment. Besides, macrophages are the major components of the innate immune system and play a critical role in the inflammation process in SLE. Secoiridoids from olive tree are phenolic compounds which have shown important pharmacological effects. Particularly, oleuropein (OL) has shown antioxidant, anti-inflammatory and immunomodulatory properties suggesting a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases. In addition, different studies have shown the importance of acyl derivatives of natural phenols due to their better hydrophilic/lipophilic balance.
Keyphrases
- systemic lupus erythematosus
- reactive oxygen species
- anti inflammatory
- oxidative stress
- disease activity
- inflammatory response
- diabetic rats
- immune response
- dna damage
- fatty acid
- drug induced
- cell death
- high glucose
- lipopolysaccharide induced
- multiple sclerosis
- high fat diet induced
- rheumatoid arthritis
- liquid chromatography
- type diabetes
- lps induced
- combination therapy
- nlrp inflammasome
- climate change
- human health
- mass spectrometry