Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis.

Rui YangSijin ChengNan LuoRanran GaoKezhuo YuBoxi KangLi WangQiming ZhangQiao FangLei ZhangChen LiAibin HeXueda HuJirun PengXianwen RenYuanyuan Zhang

Published in: Genome biology (2019)

Our study supports the involvement of DNA methylation in shaping tumor-reactive and bystander CD8+ TILs, and provides a valuable resource for the development of novel DNA methylation markers and future therapeutics.

Keyphrases

dna methylation
genome wide
gene expression
end stage renal disease
newly diagnosed
copy number
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
small molecule