Methylation of the Vitamin D Receptor Gene in Human Disorders.
Beatrice GasperiniAngela FalvinoEleonora PiccirilliUmberto TarantinoAnnalisa BottaVirginia Veronica ViscontiPublished in: International journal of molecular sciences (2023)
The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH) 2 D 3 ), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.
Keyphrases
- dna methylation
- genome wide
- copy number
- endothelial cells
- infectious diseases
- gene expression
- induced apoptosis
- induced pluripotent stem cells
- oxidative stress
- pluripotent stem cells
- squamous cell carcinoma
- papillary thyroid
- bone mineral density
- endoplasmic reticulum stress
- postmenopausal women
- body composition
- young adults
- cell cycle arrest
- transcription factor
- genome wide identification