Towards a youth mental health paradigm: a perspective and roadmap.
Peter J UhlhaasChristopher G DaveyUrvakhsh Meherwan MehtaJai ShahJohn B TorousNicholas B AllenShelli AvenevoliTolulope Bella-AwusahAndrew ChanenEric Y H ChenChristoph U CorrellKim Quang DoHelen L FisherSophia FrangouIan B HickieMatcheri S KeshavanKerstin KonradFrancis S LeeCindy H LiuBeatriz LunaPatrick D McGorryAndreas Meyer-LindenbergMerete NordentoftDost ÖngürGeorge C PattonTomáš PausUlrich ReininghausAkira SawaMichael SchoenbaumGunter SchumannVinod H SrihariEzra S SusserSwapna K VermaT Wilson WooLawrence H YangAlison Ruth YungStephen J WoodPublished in: Molecular psychiatry (2023)
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health. This perspective addresses interactions between risk and protective factors and brain development as key pillars accounting for the emergence of psychopathology in youth. Moreover, we propose that novel approaches towards early diagnosis and interventions are required that reflect the evolution of emerging psychopathology, the importance of novel service models, and knowledge exchange between science and practitioners. Taken together, we propose a transformative early intervention paradigm for research and clinical care that could significantly enhance mental health in young people and initiate a shift towards the prevention of severe mental disorders.
Keyphrases
- mental health
- healthcare
- mental illness
- public health
- anorexia nervosa
- randomized controlled trial
- physical activity
- primary care
- palliative care
- resting state
- quality improvement
- early onset
- functional connectivity
- multiple sclerosis
- social media
- general practice
- cerebral ischemia
- drug induced
- subarachnoid hemorrhage