Catalytic Reductive Cross-Coupling between Aromatic Aldehydes and Arylnitriles.
Atsuhisa MitsuiKazunori NagaoHirohisa OhmiyaPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)
A reductive cross-coupling reaction between aromatic aldehydes and arylnitriles using a copper catalyst and a silylboronate as a reductant is reported. This protocol represents an unprecedented approach to the chemoselective synthesis of α-hydroxy ketones by electrophile-electrophile cross-coupling.