Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis.

Shu-Quan LvLirong FanXiaoting ChenXiuhai SuLi DongQinghai WangYuansong WangHui ZhangHuan-Tian CuiShufang ZhangLixin Wang

Published in: Journal of diabetes research (2024)

JPGS has significant therapeutic and anti-inflammatory effects on DN mice, and its mechanism is mainly achieved by upregulating the expression of GPX4 pathway-related proteins, thereby alleviating iron overload and ultimately reducing ferroptosis.

Keyphrases

diabetic nephropathy
cell death
anti inflammatory
high fat diet induced
poor prognosis
insulin resistance
wild type
type diabetes
adipose tissue
long non coding rna
skeletal muscle
iron deficiency