Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine and parasite resistance: cross-sectional surveys from antenatal care visit and delivery in rural Ghana.
Atikatou MamaCharity AhiaborBernard TornyigahNaa Adjeley FrempongKwadwo A KusiBright AduDavid CourtinSandrine HouzéPhilippe DeloronMichael F OforiAbraham K AnangFrédéric ArieyNicaise Tuikue NdamPublished in: Malaria journal (2022)
This study confirms a positive impact following the implementation of the new IPTp-SP policy in Ghana in increasing the birth weight of newborns. However, the selection pressure exerted by the recommended 3 or more doses of IPTp-SP results in the emergence of parasites carrying the non-synonymous mutation on codon A581G. This constant selective pressure calls into question the time remaining for the clinical utility of IPTp-SP treatment during pregnancy in Africa.
Keyphrases
- cross sectional
- healthcare
- birth weight
- pregnant women
- gestational age
- preterm birth
- quality improvement
- primary care
- public health
- mental health
- weight gain
- palliative care
- south africa
- physical activity
- body mass index
- combination therapy
- high intensity
- preterm infants
- replacement therapy
- smoking cessation
- cord blood
- weight loss