Blood draws up to 3% of blood volume in clinical trials are safe in children.
Claudia PeplowRobin AssfalgAndreas BeyerleinJoerg HasfordEzio BonifacioAnette-Gabriele ZieglerPublished in: Acta paediatrica (Oslo, Norway : 1992) (2018)
Regular blood draws of up to 3% of total blood volume were not associated with signs of anaemia or hypovolaemia in young children. We suggest that the European recommendations be revised for clinical studies in which children are not exposed to treatments that are associated with anaemia risk.