Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway.
Chao HuangWenbo ZhangAijun SunXi ZhangJinping GuoRuijuan JiLiang QiaoXue-Jun SunDong Bao ZhaoPublished in: Oxidative medicine and cellular longevity (2020)
It was found that methane significantly prolonged rat survival, decreased the W/D ratio, alleviated LPS-induced histological changes, and reduced apoptotic cells in the testes. Additionally, methane suppressed and promoted the production of pro- and anti-inflammatory cytokines, respectively. Furthermore, methane significantly increased SOD levels, decreased MDA levels, and decreased testicular expression of PK2 and PKR1. Therefore, methane exerts therapeutic effects on acute orchitis and might be a new and convenient strategy for the treatment of inflammation-related testicular diseases.
Keyphrases
- anaerobic digestion
- anti inflammatory
- lipopolysaccharide induced
- inflammatory response
- lps induced
- carbon dioxide
- liver failure
- oxidative stress
- respiratory failure
- cell cycle arrest
- drug induced
- cell death
- poor prognosis
- aortic dissection
- mouse model
- binding protein
- cell proliferation
- amyotrophic lateral sclerosis
- long non coding rna
- extracorporeal membrane oxygenation