IL-17A and TNF Modulate Normal Human Spinal Entheseal Bone and Soft Tissue Mesenchymal Stem Cell Osteogenesis, Adipogenesis, and Stromal Function.
Tobias RussellAbdulla WatadCharlie BridgewoodHannah RoweAlmas KhanAbhay RaoPeter LoughenburyPeter MillnerRobert DunsmuirRichard CuthbertAla AltaieElena A JonesDennis McGonaglePublished in: Cells (2021)
Normal spinal enthesis harbors resident MSCs with different in vitro functionalities in bone and soft tissue, especially in response to IL-17A, which enhanced osteogenesis and CCL20 production and reduced adipogenesis compared to unstimulated MSCs. This MSC-stromal-enthesis immune system may be a hitherto unappreciated mechanism of "fine tuning" tissue repair responses at the enthesis in health and could be relevant for SpA understanding.
Keyphrases
- soft tissue
- mesenchymal stem cells
- bone marrow
- umbilical cord
- spinal cord
- endothelial cells
- bone regeneration
- public health
- healthcare
- rheumatoid arthritis
- air pollution
- high fat diet induced
- patient safety
- cell therapy
- induced pluripotent stem cells
- bone mineral density
- pluripotent stem cells
- quality improvement
- health information
- liver injury
- type diabetes
- insulin resistance
- body composition