Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway.
Shengjie LiuYuanmei WangHanlin YangJun TanJingkaiwen ZhangDan ZiPublished in: Stem cell research & therapy (2024)
Our research findings indicate that PQQ facilitates MSC-Mito proliferation and, in combination with MSC-Mito, ameliorates chemotherapy-induced POI through the SIRT1/ATM/p53 signaling pathway.
Keyphrases
- signaling pathway
- chemotherapy induced
- dna damage
- dna repair
- dna damage response
- endothelial cells
- oxidative stress
- ischemia reperfusion injury
- pi k akt
- stem cells
- bone marrow
- epithelial mesenchymal transition
- induced pluripotent stem cells
- induced apoptosis
- cell death
- pluripotent stem cells
- high fat diet induced
- mouse model
- reactive oxygen species
- type diabetes
- skeletal muscle
- metabolic syndrome
- cell proliferation