Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp.
Lu-Lin XuPing HaiShuai-Bing ZhangJing-Fang XiaoYuan GaoBing-Ji MaHai-Yan FuYe-Miao ChenXiao-Long YangPublished in: Journal of natural products (2019)
Ten new prenylated indole diterpene alkaloids, tolypocladin A-J (1-10), including four chlorinated metabolites, have been isolated from a culture of a mine-soil-derived fungus, Tolypocladium sp. XL115. The structures and absolute configurations of 1-10 were determined by spectroscopic analysis, ECD calculations, and comparison with known compounds. Compounds 1 and 8 displayed significant antimicrobial activities. In addition, compound 1 also showed weak cytotoxic activity against all tested human cancer cell lines and suppressed the growth and viability of the patient-derived HCC cells T1224.
Keyphrases
- induced apoptosis
- endothelial cells
- papillary thyroid
- cell cycle arrest
- molecular docking
- staphylococcus aureus
- molecular dynamics
- high resolution
- density functional theory
- squamous cell
- molecular dynamics simulations
- induced pluripotent stem cells
- plant growth
- pluripotent stem cells
- cell death
- oxidative stress
- monte carlo
- tandem mass spectrometry