Insulin resistance in patients with cancer: a systematic review and meta-analysis.
Joan M MàrmolMichala CarlssonSteffen H RaunMia K GrandJonas SørensenLouise Lang LehrskovErik Arne RichterOle NorgaardLykke SylowPublished in: Acta oncologica (Stockholm, Sweden) (2023)
These findings suggest that patients with a cancer diagnosis are markedly insulin resistant. As metabolic dysfunction in patients with cancer associates with increased recurrence and reduced overall survival, future studies should address if ameliorating insulin resistance in this population can improve these outcomes thereby improving patient care.Key pointsMetabolic dysfunction increases cancer recurrence rates and reduces survival for patients with cancer.Insulin resistance is a critical cause of metabolic dysfunctions.To date, no comprehensive compilation of research investigating insulin resistance in cancer patients has been produced.In this meta-analysis, we found that patients with various cancers were markedly insulin-resistant.
Keyphrases
- type diabetes
- free survival
- papillary thyroid
- systematic review
- insulin resistance
- squamous cell
- glycemic control
- oxidative stress
- case control
- adipose tissue
- metabolic syndrome
- randomized controlled trial
- childhood cancer
- skeletal muscle
- squamous cell carcinoma
- polycystic ovary syndrome
- meta analyses
- high fat diet induced