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Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient.

Hope BaroneRoss BrockmanLuke JohnsonAmira Al-UzriMary WrightStephanie Mengden-KoonTracy Funk
Published in: Pediatric transplantation (2019)
Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin-colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9-year-old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as "lichen nitidus," and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware.
Keyphrases
  • primary care
  • case report
  • soft tissue
  • stem cells
  • squamous cell carcinoma
  • early onset
  • mesenchymal stem cells
  • locally advanced
  • radiation therapy
  • cell therapy
  • advanced cancer