Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in Korea: a phase III randomized trial.

J KimB-K SuhC W KoK-H LeeC H ShinJ S HwangH S KimW Y ChungC J KimH-S HanN Y KwonSung Yoon ChoH-W YooD-K Jin

Published in: Journal of endocrinological investigation (2017)

One-year GH treatment for prepubertal children with ISS demonstrated increased annualized velocity, height and weight SDSs, and IGF-1 and IGFBP-3 levels, with a favorable safety profile. Further evaluations are needed to determine the optimal dose, final adult height, and long-term effects of ISS treatment.

Keyphrases

growth hormone
body mass index
phase iii
young adults
clinical trial
open label
physical activity
randomized controlled trial
phase ii
study protocol
cell free
binding protein
replacement therapy