Mice Lacking Gpr75 are Hypophagic and Thin.
David R PowellDeon D DoreeChristopher M DaCostaKenneth A PlattRobert BrommageLindsey BuhringJean-Pierre RevelliMelanie K ShadoanPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2022)
KO mice are thin at weaning, are hypophagic as the thin phenotype becomes more exaggerated, and exhibit improved glucose tolerance and insulin sensitivity as healthy-appearing adults. These results suggest that inhibiting GPR75 in obese humans may safely decrease energy intake and body fat while improving glucose tolerance and insulin sensitivity.