S100 proteins in cardiovascular diseases.
Yue ZhouYiwen ZhaYongqi YangTan MaHongliang LiJingyan LiangPublished in: Molecular medicine (Cambridge, Mass.) (2023)
Cardiovascular diseases have become a serious threat to human health and life worldwide and have the highest fatality rate. Therefore, the prevention and treatment of cardiovascular diseases have become a focus for public health experts. The expression of S100 proteins is cell- and tissue-specific; they are implicated in cardiovascular, neurodegenerative, and inflammatory diseases and cancer. This review article discusses the progress in the research on the role of S100 protein family members in cardiovascular diseases. Understanding the mechanisms by which these proteins exert their biological function may provide novel concepts for preventing, treating, and predicting cardiovascular diseases.
Keyphrases
- cardiovascular disease
- human health
- public health
- risk assessment
- cardiovascular risk factors
- type diabetes
- cardiovascular events
- poor prognosis
- stem cells
- climate change
- oxidative stress
- binding protein
- cell therapy
- squamous cell carcinoma
- coronary artery disease
- single cell
- mesenchymal stem cells
- metabolic syndrome