BRCA1 methylation in newborns: genetic disposition, maternal transfer, environmental influence, or by chance only?
Per Eystein LønningStian KnappskogPublished in: Clinical epigenetics (2018)
In this letter, we respond to and discuss the recent publication by Al-Moghrabi et al.: Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters. We discuss their findings with emphasis on two other recently published papers and argue that their data allows no conclusion regarding the transmission of BRCA1 methylation from parent to child.
Keyphrases
- genome wide
- dna methylation
- induced apoptosis
- breast cancer risk
- copy number
- mental health
- cell cycle arrest
- pregnant women
- gene expression
- electronic health record
- big data
- transcription factor
- oxidative stress
- randomized controlled trial
- endoplasmic reticulum stress
- systematic review
- cord blood
- data analysis
- artificial intelligence
- climate change
- deep learning
- preterm infants