Sox2 Expression Marks Castration-Resistant Progenitor Cells in the Adult Murine Prostate.
Erin M McAuleyDaniel MolineCalvin VanOpstallSophia LamperisRyan BrownDonald J Vander GriendPublished in: Stem cells (Dayton, Ohio) (2019)
Identification of defined epithelial cell populations with progenitor properties is critical for understanding prostatic development and disease. Here, we demonstrate that Sox2 expression is enriched in the epithelial cells of the proximal prostate adjacent to the urethra. We use lineage tracing of Sox2-positive cells during prostatic development, homeostasis, and regeneration to show that the Sox2 lineage is capable of self-renewal and contributes to prostatic regeneration. Persisting luminal cells express Sox2 after castration, highlighting a potential role for Sox2 in cell survival and castration-resistance. In addition to revealing a novel progenitor population in the prostate, these data implicate Sox2 as a regulatory factor of adult prostate epithelial stem cells. Stem Cells 2019;37:690-700.
Keyphrases
- stem cells
- benign prostatic hyperplasia
- transcription factor
- prostate cancer
- induced apoptosis
- radical prostatectomy
- poor prognosis
- cell therapy
- cell cycle arrest
- long non coding rna
- cell fate
- mesenchymal stem cells
- electronic health record
- binding protein
- signaling pathway
- deep learning
- endoplasmic reticulum stress