Efficacy and safety of oral sirolimus for high-flow vascular malformations in real clinical practice.

Antonio-José Durán-RomeroJ C Hernández-RodríguezJ Ortiz-ÁlvarezJ J Domínguez-CruzM T Monserrat-GarcíaJ Conejo-Mir SánchezJ Bernabeu-Wittel

Published in: Clinical and experimental dermatology (2021)

Our results show that oral sirolimus is a well-tolerated therapeutic option, with an excellent safety profile, which can be useful in the long-term stabilization of patients with high-flow vascular malformations. Single-daily dosage may improve long-term adherence to treatment without worsening its effectiveness.

Keyphrases

clinical practice
randomized controlled trial
systematic review
physical activity
metabolic syndrome
adipose tissue
insulin resistance
combination therapy
smoking cessation