Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the Adiponectin Receptor 2/PPAR-α Axis.
Fabiane Valentini FrancisquetiArtur Junio Togneri FerronFabiana Kurokawa HasimotoPedro Henrique Rizzi AlvesJéssica Leite GarciaKlinsmann Carolo Dos SantosFernando MoretoVanessa Dos Santos SilvaAna Lúcia A FerreiraIgor Otávio MinatelCamila Renata CorrêaPublished in: Oxidative medicine and cellular longevity (2018)
The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol (γOz) is a compound with antioxidant and anti-inflammatory activity that has shown a positive action in the treatment of obesity and metabolic diseases. Aim. To evaluate the effect of γOz to recover renal function in obese animals by high sugar-fat diet by modulation of adiponectin receptor 2/PPAR-α axis Methods. Male Wistar rats were initially randomly divided into 2 experimental groups: control and high sugar-fat diet (HSF) for 20 weeks. When proteinuria was detected, HSF animals were allocated to receive γOz or maintain HSF for more than 10 weeks. The following were analyzed: nutritional and biochemical parameters, systolic blood pressure, and renal function. In the kidney, the following were evaluated: inflammation, oxidative stress, and protein expression by Western blot. Results. After 10 weeks of γOz treatment, γOz was effective to improve inflammation, increase antioxidant enzyme activities, increase the protein expression of adiponectin receptor 2 and PPAR-α, and recover renal function. Conclusion. These results permit us to confirm that γOz is able to modulate PPAR-α expression, inflammation, and oxidative stress pathways improving obesity-induced renal disease.
Keyphrases
- insulin resistance
- oxidative stress
- metabolic syndrome
- diabetic rats
- adipose tissue
- weight loss
- high fat diet induced
- heat shock
- blood pressure
- chronic kidney disease
- skeletal muscle
- type diabetes
- ischemia reperfusion injury
- induced apoptosis
- uric acid
- dna damage
- fatty acid
- bariatric surgery
- heart failure
- high glucose
- gestational age
- physical activity
- binding protein
- cardiovascular risk factors
- south africa
- drug induced
- glycemic control
- left ventricular
- weight gain
- hypertensive patients
- anti inflammatory
- heat stress