Immune response induced by standard and fractional doses of 17DD yellow fever vaccine.
Thais Abdala-TorresAna Carolina Campi-AzevedoRosiane Aparecida da Silva-PereiraLuara Isabela Dos SantosPriscilla Miranda HenriquesIsmael Artur Costa-RochaDayane Andriotti OttaVanessa Peruhype-MagalhãesAndréa Teixeira-CarvalhoMárcio Sobreira Silva AraújoEder Gatti FernandesHelena Keico SatoFrancieli Fontana Sutile Tardetti FantinatoCarla Magda Allan Santos DominguesEsper Georges KallásHelena Tomoko Iwashita TomiyamaJandira Aparecida Campos LemosJordana Grazziela Coelho-Dos-ReisSheila Maria Barbosa de LimaWaleska Dias SchwarczAdriana de Souza AzevedoGisela Freitas TrindadeAna Paula Dinis Ano BomAndrea Marques Vieira da SilvaCamilla Bayma FernandesLuiz Antônio Bastos CamachoMaria de Lourdes de Sousa Maianull nullOlindo Assis Martins-FilhoLis Ribeiro do Valle do AntonelliPublished in: NPJ vaccines (2024)
The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization approved the use of the fractional dose (FD) of the YF vaccine due to stock shortage. In an observational cross-sectional investigation, we have assessed viremia, antibodies, soluble mediators and effector and memory T and B-cells induced by primary vaccination of volunteers with FD and standard dose (SD). Similar viremia and levels of antibodies and soluble markers were induced early after immunization. However, a faster decrease in the latter was observed after SD. The FD led to a sustained expansion of helper T-cells and an increased expression of activation markers on T-cells early after vaccination. Although with different kinetics, expansion of plasma cells was induced upon SD and FD immunization. Integrative analysis reveals that FD induces a more complex network involving follicular helper T cells and B-cells than SD. Our findings substantiate that FD can replace SD inducing robust correlates of protective immune response against YF.