Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression.
Ali S RopriTiffany G LamVrinda KaliaHeather M BuchananAnne Marie W BartoschElliot H H YouthHarrison XiaoSophie K RossAnu JainJayanta K ChakrabartyMin Suk KangDeborah BoyettEleonora F SpinazziGail IodiceRobert A McGovernLawrence S HonigLewis M BrownGary W MillerGuy M McKhannAndrew F TeichPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
AD CSF biomarkers correlate with CNS pathology and transcriptomic changes. Seven proteins correlate with CNS pathology and gene expression changes. Inflammatory and neuronal gene expression changes correlate with YKL-40 and NPTXR, respectively. CSF metabolomic analysis identifies pathways that correlate with biopsy data. Fatty acid metabolic pathways correlate with β-amyloid pathology.