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Comparative Study of Predominant Phytochemical Compounds and Proapoptotic Potential of Broccoli Sprouts and Florets.

Paweł PaśkoMałgorzata Tyszka-CzocharaAgnieszka GalantyJoanna Gdula-ArgasińskaPaweł ŻmudzkiHenryk BartońPaweł ZagrodzkiShela Gorinstein
Published in: Plant foods for human nutrition (Dordrecht, Netherlands) (2018)
The study compares lyophilized broccoli sprouts and florets in terms of their chemical composition, cytotoxic and proapoptotic potential against hepatocellular carcinoma HepG2, colorectal cancer SW480, and skin fibroblast BJ cells. Sinapic and isochlorogenic acids were predominant phenolics in the sprouts and florets, respectively. The amount of sulforaphane in the sprouts was significantly higher vs. florets. Oleic and linoleic acids dominated in the sprouts, while caproic, stearic and oleic acids in the florets. Broccoli sprouts were selectively cytotoxic on HepG2 and SW480 cells, with proapoptotic effect for the latter, while the florets were less selective, but more active, with profound proapoptotic effect for HepG2 cells (77.4%). Thus, lyophilized broccoli sprouts may be effectively used in dietary chemoprevention.
Keyphrases
  • induced apoptosis
  • endoplasmic reticulum stress
  • human health
  • cell proliferation
  • intellectual disability