Wound Modulations in Glaucoma Surgery: A Systematic Review.
Bhoomi DaveMonica PatelSruthi SureshMahija GinjupalliArvind SuryaMohannad AlbdourKaranjit S KoonerPublished in: Bioengineering (Basel, Switzerland) (2024)
Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there is a need to develop novel treatments which provide increased effectiveness and specificity. This review aims to provide insight into the pathophysiology behind wound healing in glaucoma surgery, as well as the current and promising future wound healing agents that are less toxic and may provide better IOP control.
Keyphrases
- wound healing
- minimally invasive
- coronary artery bypass
- surgical site infection
- optic nerve
- randomized controlled trial
- cataract surgery
- systematic review
- systemic sclerosis
- stress induced
- idiopathic pulmonary fibrosis
- current status
- weight gain
- skeletal muscle
- insulin resistance
- adipose tissue
- acute coronary syndrome
- optical coherence tomography