Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis.
Sine WichmannMarija BarbateskovicNing LiangTheis Skovsgaard ItenovRasmus Ehrenfried BerthelsenJane LindschouAnders PernerChristian GluudMorten Heiberg BestlePublished in: Annals of intensive care (2022)
The evidence is very uncertain about the effect of loop diuretics on mortality and serious adverse events in adult ICU patients with fluid overload. Loop diuretics may reduce the occurrence of these outcomes, but large randomised placebo-controlled trials at low risk of bias are needed.
Keyphrases
- clinical trial
- placebo controlled
- double blind
- phase ii
- phase iii
- study protocol
- open label
- systematic review
- transcription factor
- phase ii study
- risk assessment
- intensive care unit
- randomized controlled trial
- childhood cancer
- coronary artery disease
- cardiovascular events
- young adults
- cardiovascular disease
- type diabetes
- rectal cancer
- extracorporeal membrane oxygenation
- metabolic syndrome