Resveratrol sensitizes selectively thyroid cancer cell to 131-iodine toxicity.
Seyed Jalal HosseinimehrSeyed Amir Hossein HosseiniPublished in: Journal of toxicology (2014)
Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by (131)I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against (131)I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy.
Keyphrases
- induced apoptosis
- cell death
- oxidative stress
- single cell
- cell cycle arrest
- cell proliferation
- endothelial cells
- cell therapy
- endoplasmic reticulum stress
- stem cells
- high throughput
- cell cycle
- magnetic resonance imaging
- computed tomography
- mass spectrometry
- pluripotent stem cells
- mesenchymal stem cells
- newly diagnosed
- atomic force microscopy
- replacement therapy