Sex differences in the effects of repeated ketamine infusions on bone markers in patients with unipolar and bipolar depression.
Xiaofeng LanHaiyan LiuChengyu WangWeicheng LiFan ZhangZhibo HuXiaoyu ChenZerui YouYuping NingYanling ZhouPublished in: Biology of sex differences (2024)
Our results suggest that repeated ketamine infusions may be associated with modulation of bone markers in patients with depression and present sex differences. Baseline osteocalcin level may be served as a predictor for the antidepressant effects of ketamine in males. Trial registration Data were derived from an open label clinical trial, which was registered at Chinese Clinical Trial Registry (ChiCTR-OOC-17012239). Registered 26 May 2017. http://www.chictr.org.cn.
Keyphrases
- clinical trial
- phase ii
- pain management
- phase iii
- study protocol
- bone mineral density
- depressive symptoms
- open label
- sleep quality
- soft tissue
- double blind
- bone loss
- bone regeneration
- major depressive disorder
- randomized controlled trial
- electronic health record
- big data
- physical activity
- squamous cell carcinoma
- chronic pain
- machine learning
- artificial intelligence