Diagnostic utility of FOXO1 immunohistochemistry for rhabdomyosarcoma classification.

Cooper D RutlandJodi GedallovichAihui WangSabrina ZdravkovicSushama VarmaJason L Hornick Gregory W Charville

Published in: Histopathology (2023)

Taken together, our findings suggest that FOXO1 immunohistochemistry is a highly sensitive and relatively specific surrogate marker of the PAX3/7::FOXO1 fusion oncoprotein in rhabdomyosarcoma. Cytoplasmic immunoreactivity, expression in nonneoplastic tissues, and limited nuclear staining of nonalveolar rhabdomyosarcomas represent potential pitfalls in interpretation.

Keyphrases

transcription factor
pi k akt
signaling pathway
poor prognosis
machine learning
deep learning
gene expression
human health
high resolution
mass spectrometry