Different medications for the treatment of Ménière's disease by intratympanic injection: A systematic review and network meta-analysis.

Zuwei CaoFengjuan YueWei HuangDeepak RajenderkumarFei Zhao

Published in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2019)

All medications are more effective than a placebo in the treatment of Ménière's disease by intratympanic injection. According to the SUCRA, Gentamicin ranked the most effective, with Gentamicin and Methylprednisolone equally effective in the long-term effect. When the potential risk of hearing loss induced by Gentamicin is taken into consideration, Methylprednisolone may be the best choice for the treatment of Ménière's disease by intratympanic injection.

Keyphrases

randomized controlled trial
clinical trial
ultrasound guided
risk assessment
combination therapy
open label
phase iii