Comparing tuberculosis gene signatures in malnourished individuals using the TBSignatureProfiler.

William Evan JohnsonAubrey OdomChelsie CintronMutharaj MuthaiahSelby KnudsenNoyal JosephSenbagavalli BabuSubitha LakshminarayananDavid F JenkinsYue ZhaoEthel NankyaC Robert HorsburghGautam RoyJerrold EllnerSonali SarkarPadmini SalgameNatasha S Hochberg

Published in: BMC infectious diseases (2021)

Our TBSignatureProfiler is a highly effective and user-friendly platform for applying and comparing published TB signature gene sets. Using this platform, we found that existing gene sets for TB function effectively in the setting of malnutrition, although differences in gene set applicability exist. RNA-sequencing gene sets should consider comorbidities and potential effects on diagnostic performance.

Keyphrases

genome wide
copy number
mycobacterium tuberculosis
genome wide identification
high throughput
systematic review
emergency department
gene expression