Optimized Cationic Lipid-assisted Nanoparticle for Delivering CpG Oligodeoxynucleotides to Treat Hepatitis B Virus Infection.

Yi-Fang ChenYan WangYue WangYing-Li LuoZi-Dong LuXiao-Jiao DuCong-Fei XuJun Wang

Published in: Pharmaceutical research (2022)

We screened an optimized CLAN fabricated with DOTAP for efficient delivery of CpG ODNs to pDCs and cDCs, which can act as a therapeutic vaccine adjuvant for treating HBV infection.

Keyphrases

dna methylation
hepatitis b virus
early stage
liver failure
fatty acid
gene expression