Multinational Genome-Wide Association Study and Functional Genomics Analysis Implicates Decreased SIRT3 Expression Underlying Intracranial Aneurysm Risk.

Published in: Neurosurgery (2022)

We perform a multinational GWAS of IA and identify 4 genetic risk loci, including 2 novel IA risk loci ( SIRT3 and AL359922.1 ). Identification of high-risk genetic loci across ancestries will enable population-genetic screening approaches to identify patients with IA.

Keyphrases

genome wide association study
genome wide
dna methylation
oxidative stress
poor prognosis
coronary artery
ischemia reperfusion injury
long non coding rna
binding protein
breast cancer risk