Genomic and Immunophenotypic Landscape of Acquired Resistance to PD-(L)1 Blockade in Non-Small-Cell Lung Cancer.

Biagio Ricciuti Giuseppe LambertiSreekar R PuchalaNavin R MahadevanJia-Ren LinJoao M Victor AlessiAlexander ChowdhuryYvonne Y LiXinan WangLiam SpurrFederica PecciAlessandro Di FedericoDeepti VenkatramanAdriana P Barrichello Malini M GandhiVictor R VazAndy J PangilinanDanielle HaradonElinton LeeHersh V Gupta Kathleen L Pfaff Emma L Welsh Mizuki NishinoAndrew D CherniackBruce E Johnson Jason L Weirather Ian D DrygScott J RodigLynette M Sholl Peter Karl SorgerSandro SantagataRenato Umeton Mark M Awad

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

These findings highlight the genomic and immunophenotypic heterogeneity of ICI resistance in NSCLC, which will need to be considered when developing novel therapeutic strategies aimed at overcoming resistance.

Keyphrases

small cell lung cancer
single cell
copy number
gene expression
dna methylation