Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in Mice.

Yingzheng WangPawat PattarawatJiyang ZhangEunchong KimDelong ZhangMingzhu FangElizabeth A JannamanYe YuanSaurabh ChatterjeeJi-Yong Julie KimGeoffrey I ScottQiang ZhangShuo Xiao

Published in: Environmental health perspectives (2023)

murine and human model systems, we provide data suggesting that environmentally relevant exposure to the CyanoHAB toxin MC-LR interfered with gonadotropin-dependent follicle maturation and ovulation. We conclude that MC-LR may pose a nonnegligible risk to women's reproductive health by heightening the probability of irregular menstrual cycles and infertility related to ovulatory disorders. https://doi.org/10.1289/EHP12034.

Keyphrases

polycystic ovary syndrome
escherichia coli
insulin resistance
endothelial cells
high fat diet induced
induced pluripotent stem cells
type diabetes
adipose tissue
big data
pluripotent stem cells
deep learning
wild type