Intraperitoneal monocytes and interferons as a novel cellular immunotherapy for ovarian cancer: mechanistic characterization and results of a phase I clinical trial.

Daniel S Green Franklin Ning Anna Duemler Timothy G Myers Kathryn Trewitt Irene Ekwede Ann McCoy Nicole Houston Jung-Min Lee Stanley Lipkowitz Alexandra S Zimmer Miroslava Pavelova Erin N Villanueva Leslie Smith Andrew M Blakely Yovanni Casablanca Steven L Highfill David F Stroncek Naoza Collins-Johnson Sandhya R Panch JoLynn Procter Chauha Pham Steven M Holland Lindsey B Rosen Ana T Nunes Kathryn C Zoon Christopher B Cole Christina M Annunziata

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Given the mechanism of cancer cell death, and the acceptable tolerability of the clinical regimen, this platform presents a possibility for future combination therapies to augment anti-cancer immunity.

Keyphrases

cell death
clinical trial
open label
papillary thyroid
double blind
squamous cell
phase ii
current status
high throughput
dendritic cells
cell cycle arrest
peripheral blood
study protocol
squamous cell carcinoma
lymph node metastasis
randomized controlled trial
childhood cancer
placebo controlled
cell proliferation