Copper-mediated bromine atom transfer radical cyclisation of unactivated alkyl bromides.
Xue YangJianlin ZhouShuoren WuWei YuPublished in: Chemical communications (Cambridge, England) (2023)
The atom transfer radical cyclisation of unactivated alkyl bromides was realized by using a catalytic system of CuBr and Me 6 -TREN. This protocol is applicable to the preparation of five-membered rings from unsaturated primary and secondary bromides.