Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism.
Emily M PujadasXiaolong WeiNicolas AcostaLucas CarterJiekun YangLuay Matthew AlmassalhaAli DaneshkhahSuhas S P RaoVasundhara AgrawalFidan Seker-PolatErez Lieberman AidenMasato T KanemakiVadim BackmanMazhar AdliPublished in: bioRxiv : the preprint server for biology (2023)
Our findings suggest that the mechanistic role of B-type lamins is stabilization of heterochromatin and chromosomal positioning along the nuclear periphery. We conclude that degrading lamin B1 and lamin B2 has several functional consequences related to both structural disease and cancer.