The combined immunohistochemical expression of AMBRA1 and SQSTM1 identifies patients with poorly differentiated cutaneous squamous cell carcinoma at risk of metastasis: A proof of concept study.

Michael H AlexanderWilliam J CousinsTom EwenAndrew P SouthPenny LovatNiki Stefanos

Published in: Journal of cutaneous pathology (2024)

Collectively, these proof of concept data suggest loss of the combined expression of AMBRA1 in the cSCC growth front and SQSTM1 in the peritumoral epidermis as a putative prognostic biomarker for poorly differentiated cSCC.

Keyphrases

poor prognosis
squamous cell carcinoma
binding protein
long non coding rna
big data
radiation therapy
dna methylation