Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma.

Hye Ri AhnGeum Ok BaekMoon Gyeong YoonJu A SonJung Hwan YoonJae Youn CheongHyo Jung ChoHo Chul KangJung Woo EunSoon Sun Kim

Published in: Journal of experimental & clinical cancer research : CR (2022)

WASF2 is overexpressed and hypomethylated in HCC and correlates with patient prognosis. WASF2 inactivation exerts anti-tumorigenic effects on HCC cells in vitro and in vivo, suggesting that WASF2 could be a potential therapeutic target for HCC.

Keyphrases

induced apoptosis
dna methylation
cell cycle arrest
gene expression
case report
signaling pathway
poor prognosis
cell proliferation
endoplasmic reticulum stress
risk assessment
cell death
human health
long non coding rna
pi k akt