State of the Science: Using Telomeres as Biomarkers During the First 1,000 Days of Life.
Sarah OertherRebecca LorenzPublished in: Western journal of nursing research (2018)
Telomere biology shows promise as an integrative biomarker of exposures and increased occurrence of chronic disease and early mortality. This integrative review examined the state of the science regarding toxicokinetic risks and maternal factors in humans and in vivo models that are correlated with telomere length during the first 1,000 days of life. The Preferred Reporting Items of Systematic Reviews and Meta-Analyses framework assisted in guiding this integrative by aiding researchers in identifying, selecting, and critically appraising the literature. Ovid MEDLINE, CINAHL, Cochrane Systematic Reviews, Web of Science, and SCOPUS databases were searched. The initial search yielded a total of 381 published articles. Full-text screening resulted in 19 articles retained for review (14 quasi-experimental studies and five experimental studies). Findings suggest a relationship between toxicokinetic exposures creating inflammation or oxidative stress (i.e., smoking) and maternal health conditions such as sleep apnea to shorter telomere length in children below 2 years old.
Keyphrases
- meta analyses
- systematic review
- public health
- sleep apnea
- oxidative stress
- randomized controlled trial
- air pollution
- case control
- healthcare
- birth weight
- smoking cessation
- obstructive sleep apnea
- pregnancy outcomes
- positive airway pressure
- big data
- young adults
- dna damage
- risk assessment
- mental health
- cardiovascular events
- network analysis
- cardiovascular disease
- pregnant women
- emergency department
- physical activity
- risk factors
- induced apoptosis
- coronary artery disease
- preterm birth
- artificial intelligence
- deep learning
- drug induced