Symptoms and SARS-CoV-2 positivity in the general population in the UK.
Karina-Doris VihtaKoen B PouwelsTim PetoEmma PritchardDavid W EyreThomas HouseOwen GethingsRuth StudleyEmma RourkeDuncan CookIan DiamondDerrick CrookPhilippa C MatthewsNicole StoesserAnn Sarah Walkernull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Expanded symptom combinations may provide modest benefits for sensitivity of PCR-based case detection, but this will vary between settings and over time, and increases tests/case. Large-scale changes to targeted PCR-testing approaches require careful evaluation given substantial resource and infrastructure implications.