SARS-CoV-2 infection in kidney transplant recipients: Experience of the italian marche region.
Federica MaritatiElisabetta CeruttiLina ZuccatostaAlessandro FiorentiniCarolina FinaleMarta FicoseccoFabrizio CristianoAlessandro CapestroEmilio BalestraDomenica TarusciaMarco VivarelliAbele DonatiGian Piero PernaAndrea GiacomettiMarcello TavioMaicol OnestaLaura Di SanteAndrea RanghinoPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2020)
The critical evaluation of all cases suggests that the timing of the administration of tocilizumab, an interleukin-6 receptor antagonist, could be associated with a better efficacy when administered in concomitance to the drop of the oxygen saturation. Thus, in SARS-CoV-2-affected KTRs, a close biochemical and clinical monitoring should be set up to allow physicians to hit the virus in the right moment such as a sudden reduction of the oxygen saturation and/or a significant increase in the laboratory values such as D-dimer.