Prognostic role of Krebs von den Lungen-6 (KL-6) measurement in idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Elena Aloisio Federica BragaChiara PuricelliMauro Panteghini

Published in: Clinical chemistry and laboratory medicine (2021)

Although our meta-analysis suggested that IPF patients with increased KL-6 concentrations had a significant increased risk of developing AE, the detection power of the evaluated biomarker is limited. Furthermore, no relationship between biomarker concentrations and mortality was found. Caution is also needed when extending obtained results to non-Asian populations.

Keyphrases

idiopathic pulmonary fibrosis
systematic review
interstitial lung disease
cardiovascular events
meta analyses
loop mediated isothermal amplification
label free
randomized controlled trial
cardiovascular disease
coronary artery disease
case control
genetic diversity
sensitive detection