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Human T cell glycosylation and implications on immune therapy for cancer.

Elien De BousserLeander MeurisNico CallewaertNele Festjens
Published in: Human vaccines & immunotherapeutics (2020)
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome. When focusing on immunity, glycans are indispensable in virtually all signaling and cell-cell interactions. More specifically, glycans have been shown to regulate key pathophysiological steps within T cell biology such as T cell development, thymocyte selection, T cell activity and signaling as well as T cell differentiation and proliferation. They are of major importance in determining the interaction of human T cells with tumor cells. In this review, we will describe the role of glycosylation of human T cells in more depth, elaborate on the importance of glycosylation in the interaction of human T cells with tumor cells and discuss the potential of cancer immunotherapies that are based on manipulating the glycome functions at the tumor immune interface. 1,2.
Keyphrases
  • endothelial cells
  • cell surface
  • pluripotent stem cells
  • squamous cell carcinoma
  • papillary thyroid
  • stem cells
  • cell therapy
  • risk assessment
  • signaling pathway