Cardiovascular Risk Associated with Alpha-1 Antitrypsin Deficiency (AATD) Genotypes: A Meta-Analysis with Meta-Regressions.

Pasquale AmbrosinoGiuseppina MarcuccioCarmen LombardiSilvestro Ennio D'AnnaStefano Sanduzzi Zamparelli Costantino Mancusi Giorgio Alfredo Spedicato Rosanna Capparelli Mauro Maniscalco

Published in: Journal of clinical medicine (2023)

Individuals with AATD may exhibit a reduced risk of ischemic heart disease, even in the presence of mild deficiency of the serine protease inhibitor. Although caution is warranted due to the observational nature of the data, future pharmacological and rehabilitation strategies should also take this controversial relationship into account.

Keyphrases

replacement therapy
electronic health record
current status
big data
cross sectional
machine learning
artificial intelligence
data analysis