BAP1-inactivated melanocytic tumor with preserved BAP1 expression? Morphology to the rescue!

Published in: Journal of cutaneous pathology (2020)

BAP1-inactivated melanocytic tumors typically present with distinctive histopathological changes and loss of nuclear BAP1 protein expression. Rare cases exhibit the typical morphology but with preserved expression of BAP1. In the current issue of Journal of Cutaneous Pathology, Linos et al. describe such a case and provide a comprehensive molecular-genetic exploration to explain such a phenomenon.

Keyphrases

poor prognosis
binding protein
gene expression
genome wide
dna methylation
copy number
single molecule